CARCINOMA OF ORAL CAVITY AND OROPHARYNX IN SMOKELESS TOBACCO USERS OF ALL AGE GROUPS
Abstract
Fifty cases clinically presenting with ulcerative lesions in oral cavity and oropharynx were biopsied. All caseshistologically revealed carcinoma. The study included 25 males and 25 females. The age range was from below 20years to above 50 years. There were 2 cases in age group up to 20 years, both were females. The maximum numberof cases (28/50) was in age group 41-60 years. All cases had positive history of oral tobacco use in the form of naswarof variable duration and quantity. All the cases clinically presented with ulcerative lesions. The maximum number ofcases was carcinoma gum (14/50). The next common site was tongue (10/50 cases). There were 7 cases of carcinomaof oropharynx. Histologically 48/50 cases were of squamous cell carcinomas of varying grades of differentiation.There was one malignant melanoma and one Adenocarcinoma.References
Pakistan Medical Research Council cancer study group.
(1977). Multicentre study of malignant tumours.
PMRC Monograph. NO.6. Karachi, Pakistan Medical
Research Council (1982)
WHO (1984) Control of Oral cancer in developing
countries. Bulletin of the World Health Organization,
: 817-830.
Metha, F.S., Pindborg, J.J. Gupta, P.C. et at. (1969).
Epidemiologic and histologic study of oral cancer and
leukoplakia among 50, 915 villagers in India. Cancer,
:832- 849
Jussawalla. D.I and Desphande, V.A (1971) Evaluation
of cancer risk in tobacco chewers and smokers; an
epidemiologic assessment. Cancer 28:244-252.
Metha, F.S., Daftary, D.K, Pindborg, J.J. et at. (1972).
An Epidemiologic study of oral cancer and
precancerous conditions, India. J. Cancer, 10:134-141.
Jafarey, N.A., Zaidi, S.H.M. (1976) Frequency of
malignant tumours in Jinnah Postgraduate Medical
Center, Karachi. JPMA., 26: 57-60.
Chaudhry, N.A. (1977) A study of carcinoma of oral
cavity and oropharynx, its relationship with herpes
simplex virus and immune status. Ph.D. Thesis, BMSI,
University of Karachi.
Jafarey, N.A., Mahmood, Z. And Zaidi, S.H.M. (1977)
Habits and dietary pattern of cases of carcinoma of oral
cavity and oropharynx. JPMA. 340-343.
IARC. Tobacco habits other than smoking, IARC
monograph n Evaluation of the carcinogenic risk of
chemical to human37, Lyon: IARC, 1985.
WHO Study Report on Smokeless Tobacco Control.
WHO, Geneva, 1987.