ROLE OF PHYTOESTROGEN IN SUPPRESSING BONE TURNOVER IN A GROUP OF POSTMENOPAUSAL WOMEN
AbstractBackground: Osteoporosis has emerged a major health hazard in postmenopausal women. Theprocess of osteoporosis accelerates two year prior to menopause, reaching the peak level during first3 years of menopause when women loss 3‒5% of their bone mass per year. This study tried to findout the role of phytoestrogne in improving the bone mineral density and bone related biochemicalparameters in group of postmenopausal women. Methods: Fifty postmenopausal women with agerange 50‒60 years were included in the study. Phytoestrogen with mineral supplement were giventwice daily for 3 months. Biochemical parameters like serum calcium, magnesium, alkalinephosphatase, uric acid, total protein and oestrogen were determined before and after phytoestrogentherapy by autoanalyser and ELIZA (oestrogen assay). T-score before and after phytoestrogen werefind out by densitometer DEXA. Results: The level of serum calcium, magnesium, uric acid andoestrogen was increased in women after taking phytoestrogen but significant difference (p<0.01) wasonly observed in case of serum calcium. Level of serum alkaline phosphatase and total serum proteinwere slightly increased with no significant different before and after phytoestrogen therapy. Value ofT-score was although markedly decreased after phytoestrogen therapy but it showed no significantdifference. Conclusion: It is concluded that as the early years of menopause are a period of rapidbone loss, and the risk for osteoporosis increases substantially, the habitual intake of soy protein andisoflavones may play a role in the retardation of bone loss.Keywords: Osteoporosis, Phytoestrogen, Postmenopausal status
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