METABOLIC EFFECTS OF ALCOHOLISM AND ITS RELATIONSHIP WITH ALCOHOLIC LIVER DISEASE

Authors

  • Fauzia Tabassum
  • Rukhshan Khurshid
  • Samina Karim
  • Mohd Saleem Akhtar

Abstract

Background. Chronic and excessive ethanol consumption is associated with cellular proliferation, fibrosis, cirrhosis and cancer ofliver. It was planned to study the effect of alcohol on different biochemical parameters as distribution of these parameters may leadto several complications in gastrointestinal tract, liver, kidney, brain etc. Methods: 50 alcoholic males and 20 normal subject (withno history of alcohol) with an age ranges 30-45 years were included in the study. Biochemical parameters related to liver wereestimated.by standard kit. Besides, ions and electrolytes were also determined by standard kit and flame photometer). Results: Itwas observed that level of alkaline phosphatase, alanine transferase, protein and globulin were significantly increased as comparedto normal subjects. Besides, ions like calcium and phosphate were significantly decreased. On the other hand, the level of potassiumand magnesium was significantly decreased as compared to normal subjects. Electrophoresis shows a protein of 100 Kda is presentin the patient’s sample as compared to control subjects. Conclusion: It is therefore concluded that abnormal biochemical functionof liver in alcoholism can lead to several complications, hence further research is needed to reach a definite conclusion.

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