SCREENING OF 110 CIRRHOTIC PATIENTS FOR HEPATITIS B AND C AT SAIDU TEACHING HOSPITAL SAIDU SHARIF SWAT
AbstractBackground: Cirrhosis liver is amongst the commonest clinical conditions in Pakistan. Besidesother causes, it is mostly related to previous viral infection, in this part of the world. The mainobjective of this study was to find the frequency of HBsAg and anti HCV in cirrhotic patients ofSwat district. Methods: This Prospective Study was conducted in the Medical unit of SaiduTeaching Hospital, Saidu Sharif from January 2006 to December 2006. One hundred and tenCirrhotic Patients, 62 Male and 48 Female aged from 14 to 75 years were included in this study.Sera were tested by 3rd generation Elisa method. Results: Fifty-nine out of 110 (53.6%) patientswere positive for anti HCV antibodies. Twenty-four (21.81%) Patients were positive for HBsAg.Eleven (10%) patients were positive for both HBsAg and anti HCV anti bodies. Sixteen (14.54%)were negative for both sero maker of hepatitis B and C. Conclusion: It is evident from this studythat Hepatitis C, is a leading cause of cirrhosis in District Swat followed by HBV. Both the virusesaccount for at least three fourths of the total Cirrhotic.Keywords: Cirrhosis liver, HBsAg, Anti HCV
Khan AA. Endemic transmission of Hepatitis C. J Coll
Physicians Surg Pak 1995;5:12–3.
Malik IA, Tariq W. The prevalence and pattern of viral
hepatitis in Pakistan (editorial). J Coll Physicians Surg Pak
Shamsuddin S. Portal systemic encephalopathy in chronic
liver disease: Experience of people Medical College, Nawab
Shah. J Coll Physicians Surg Pak 1998;8(2):53–5.
Ahmad SM, Malik IA, Tariq WUZ, Butt SA, Luqman M,
Ahmad N. Hepatitis B related chronic liver diseases in
Rawalpindi-Islamabad area. J Coll Physicians Surg Pak
Malik IA, Ahmad N, Butt SA, Tariq W, Muzaffar M, Bukhtiari
N, The role of hepatitis B & C virus in the aetiology of hepato
cellular carcinoma in northern Pakistan: a preliminary report.
J Coll Physicians Surg Pak 1995;5:26–8.
Anwaar AK, Khalil UR, Zulfiqar H and Farzana S Sero
Markers of hepatitis B and C in patients with cirrhosis. J Coll
Physicians Surg Pak 2002;12(2):105–7.
Maynard JE, khane MA, Hodersc. Global control of hepatitis
“B” through vaccine in the expended programme of
Immunization rev infect Dis 1989;11(Suppl):S574.
Javid IF, Rukhsana JF, Relative frequency of hepatitis ‘B’
virus and hepatitis ‘C’ virus infection in patients of cirrhosis
in NWFP. J Coll Physicians Surg Pak 2000;10(6):217–9.
Progress in the control of viral hepatitis memorandum from a
WHO meeting. Bull WHO 1988;66;443–55.
Abdul Baqi D, Asif B R, Hassan Sulman S and Bashirullah
M. The spectrum of chronic liver disease in Balochistan. J
Coll Physicians Surg Pak 2002;11(2):95–7.
Kuhul P, Seidal S, Stargel W, Beyer J, Sibrowski W, Flik J.
Antibody to hepatitis ‘C’ virus in German blood donors;
Saeed AA, Al Adwawi AA, Al Rashid H, Fairclough
D, Bacchus R, Ring C, et al. Hepatitis “C” virus infection in
Egyptian blood donors in Riyadh. Lancet 1991;338:459–60.
Ahmad A. Frequency of HBV surface Antigen and AntiHCV in Healthy Voluntary Blood donors in Swat district. J
Postgrad Med Inst 2006;20(2):187–90.
Khattak MF, Salamat N, Bhatti FA, Qureshi TZ.
Seroprevalence of Hepatitis B,C and HIV in blood donors in
North Pakistan. J Pak Med Assoc 2002:52:398–402.
Asif N, Khokar N, Illahi F. Seroprevalence of HBV, HCV
and HIV infection among voluntary non remunerated and
replacement donors in northern Pakistan. Pak J Med Sci
Najmul Hassain S and Ghulam Shabir. A review of published
literature on hepatitis ‘B’ and ‘C’ virus prevalence in
Pakistan. J Coll Physicians Surg Pak 2002;12(6):368–71.
Qureshi H, Zuberi SJ, Lodi TZ, Alam E. Clinical features,
course, viral makers of follow-up in young versus adult non
J Ayub Med Coll Abbottabad 2009;21(1)
alcoholic cirrhotic: a retrospective study. Digestion
Umar M, Bushra HT, Younis N, Bashir N. Clinical spectrum
of chronic liver disease due to HCV, HBV and dual infection:
a comparative study. Pak J Gastroenterol 1999;13:1–3.
Lok AS, Ma CO, Hepatitis ‘B’ virus replication in Chinese
patients with HCC. Hepatol 1990;2:285–8.
Suerlock S, Foz RA, Niazi SP, Scheuer PJ. Chronic liver
disease and primary liver cell cancer with hepatitis associated
antigen in serum. Lancet 1970;1(7659):1243.
Shah SHA, Jafari SM, Hamid S, Ahmad A, Moid I, Nadeeur-Rahman. Spectrum of chronic liver disease at a University
Hospital in Karachi. Pakistan. Pakistan J Gastroenteral
Hussain I, Nasrullah M, Shah AA. Prevalence of hepatitis ‘B’
and ‘C’ infection in liver cirrhosis in Pakistan. Pak J
Malik A, Ahmed N, Luqmon Ml. Hepatitis “C” as a cause of
chronic liver disease in Northern Pakistan. J Pak Med Assoc
Mujeeb SA, Jamal Q, Khanani R, Iqbal N, Khar S.
Prevalence of HBsAg and anti HCV antibodies in hepatocellular carcinoma cases in Karachi. Pakistan. Trop Doct
Alter MJ, Margolis HS, Krawezynski K, Judson FN, Mares
A, Alexander WJ, et al. The natural history of community
acquired hepatitis ‘C’ in the United State. N Eng J Med
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.