A COMPARATIVE STUDY OF THE EFFECT OF ACETYLCHOLINE AND PROSTAGLANDIN F2a ON ISOLATED TRACHEALIS MUSCLE OF GUINEA *PIG

Authors

  • Shah. Nawaz
  • MAJ. Kamran
  • Qazi Rashid Ahmad
  • Abdul Rashid

Abstract

Abstract: Acetylcholine and prostaglandin F2a, both produce constriction of the bronchealsmooth muscle. In present study, the bronchoconstricting effect of both these drugs wascompared by utilizing the isolated trachea of guinea-pig as experimental tissue. Results ofthe present study have shown that acetylcholine produces more powerful constriction of theisolated trachea of the guinea-pig. At high concentrations, the effect of acetylcholine wasmore poten than that of prostaglandin F2a. But in low concentrations, the bronchoconstrictingeffect of both the drugs was almost similar.

References

Larsen, G.L; and Henson, P.M. Mediators of inflammation. Annu. Rev. Immunol., 1983, I: 335-359.

Watanabe, A.M. Acetylcholine receptor stimulants. In: Basic and Clinical Pharmacology. (Ed.

Katzung, B.G.); New York, Appleton and Lange; 1987,67.

Cuthbert, M.F. Prostaglandin and respiratory smooth muscle. In: The prostaglandins: Pharmacological

and therapeutic advances (Cuthbert, M.A.Ed.). J.B. Lippincott Co. Philadelphia; 1973, pp.253-286.

Horton, E.W. Prostaglandin and smooth muscle. Br. Med. Bull. 1979, 35: 295.

Hyman, A.L. Prostaglandin and the lung. Med. Clin. North Am. 1981, 65:789.

Constantine, J.W. The spirally cut tracheal strip preparation. J. Pharm. Pharmacol., 1965, 17: 384-385.

Sasaki, S. Mechanism of leukotriene induced contraction of isolated guinea-big tracheal smooth

muscle. Lang; 1984, 162, 369

Weichman, B.M; Wasserman, M.A; and Gleason, J.G. A unique Pharmacologic antagonist of

bronchoconstriction induced by leukotriene D4, Thromboxane, Prostaglandin F2a and D2 invitro. J.

Pharmaco. Exp. Ther; 1984, 228: 128-132.

Kohorogi, H. Nifedipine inhibits human broncheal smooth muscle contractions induced by leukotriene

C4 and D4, Prostaglandin F2a and potassium. Am. Rev. Respir. Dis; 1985, 132: 299.

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