THE PREVALENCE AND PATTERN OF LIVER DISEASE IN INFANTS AND CHILDREN IN HAZARA DIVISION

Authors

  • Mumtaz Khan Burki
  • Shaukat Ali Orakzai

Abstract

Background: The pattern of the liver disease may vary in different geographical locations. These reported variationsare attributable to the differences in environmental factors, eating habits, socioeconomic factors and other reasons.We studied the pattern of liver diseases in infants and children of Hazara Division of Pakistan. Methods: 200 inpatientand outpatient infants and children in Ayub Teaching Hospital were studied from June. 1998 to October, 1999. Results:The spectrum of defect in the subjects, suffering from liver diseases showed that viral hepatitis was more common(relative frequency of 60%), followed by enteric hepatitis (26%), drug induced liver injury (7.5%), biliary atresia(5.0%) and Criglar-Najjar Syndrome (1.5%). Although both sexes were affected, however, the spectrum of liverdisease was more common in males. Moreover, viral hepatitis and enteric hepatitis were found in children aging 6 to8 years, biliary atresia in 6 months to 2 years, and drug induced liver injury in 3 to 5 years old subjects.

References

Sherlock S. Jaundice. Br. Med. J. 1962, 1:1359.

Sherlock S. Jaundice due to drugs Proce. Roy. Soc Med. 1964;

:881.

Zaman R and Orakzai S.K. Adverse effects of pyrazinamide

in Pakistani patients. JAMC. 1988; 1(2):8>.

Achor ST, Raju V.B and Sriramachari. Indian childhood

cirrhosis. J. Pediat. 1960. 57:744.

Yue P.C K & Strickland M Gueose 6 P dihydrogen age

deficiency & neonatal jaundice in change male infants in

Hongkong. Lancet 1965;-I 350

Ramsome K Problems of pediatric emergencies in Nigeree

Niger Med. J 1972,2 62

Malloy H I & Evelyn K.A. The determination of bilirubin with

photoelectric colorimeter J Biol. Chem 1937.199 481

Reitman $ & Frankel S.A Color metric method for

determination of SGDT & SGPT Am J. Clin. Path 1957:28 56.

Babson LA, Greely SJ, Coleman. CM and Philips G.D

Alkaline phosphatase phenol pathalein Method. 1966.12 482-

Gomall A G. Bardaawill (J and Biggs M G Determination of

scrum proteins b> mean of Biuret Reaction J Biol Chem

177 751

Daunt as B T. Watson W.A. and Biggs M.G. Albumin standard

& management of serum albumin with broom green Clin Chim

,31:87.

Goldenberg H and Drewes P A. Direct photometric;

determination of globulins in scrum Clin Chem. 1971.17 358

McDonald C and Barebera J Hepatitis B Quick test.

:45:277

Varley. Govenlock A H. & Maurice Bell. Practical Clinical

Chemistry !980, Vol l, pp 1061-62

Yachha S.K. Sharma. Khannduri A and Srivastaya A. Current

spectrum of hepatobiliary disorders in Northern India. Indian

Pediatr 1197,34(10):885.

Dangvval T R, Agrwal V. Malhotra V, Bavaga V and Mittal

S.K Clinical spectrum of chronic liver diseases in North India.

Trop Gastroenterol 1997:18(4): 184.

Rapicetta M, Stroffolim T. Ngatchu T, Chionne P. Ciccaglione

A. R, Lantum D and Chariamonte M. Age and sex related

study of HBV-DNA in HBsAg a symptomatic child from an

endemic area (Cameron). Ann. Trop. Paediatric.

:11(4)325.

Sadeghi E. Spectrum of Paediatric diseases in South Islamic

Republic of Iran Eastern Mediterranean Health J. 1997:

(3):519

Crigler J.F Jr and Najjar V.A. Congenital familial nonhemolytic jaundice with kernicterus. Pediatrics. 1952:10 169.

Tietz N W Clinical Guide to Laboratory tests. 1995:663; 3rd

edition WB Saunders

Most read articles by the same author(s)