• Chaman Gul
  • Zahid Irfan Marwat
  • Mohammad Israr
  • Ruhila Hanif
  • Muhammad Arshad


Background: C-reactive protein concentration has continuous associations with risk of coronary artery disease, ischemic stroke and death from several cancers. In addition, several studies have shown that CRP could be used to predict first ever myocardial infarction and stroke in healthy subjects, as well as outcome in acute setting. High levels of another biomarker, D-dimer, have been found to be independently associated with occurrence of coronary events. Methods: This correlational study was carried out at the Department of Cardiology, Ayub Teaching Hospital Abbottabad, in collaboration with the department of Biochemistry Postgraduate Medical Institute Lahore from 15th July 2013 to 15th May 2014. Patients aged 30 years or more of either gender having coronary artery disease was included in the study. Their serum D-dimer levels and C-reactive protein levels were measured for correlation with coronary artery disease. Results: A total of 50 patients of CAD were included in this study. Out of these 30 (60%) were males and 20 (40%) were females. Elevated CRP levels and D-dimer levels were noted in all of these patients. Pearson correlation coefficient test was performed on both CRP and D-dimer levels. Pearson correlation coefficient was calculated to be r= -0.1522 and when a p value was calculated, it was found to be 0.292 which implied that the results were not significant. Conclusion: This study showed that there is no correlation between CRP levels and D-dimer levels in patients with Coronary Artery Disease.Keywords: CRP; Coronary Artery Disease; Hypertension; Smoking; Family history; Diabetes Mellitus; D-dimers

Author Biography

Chaman Gul

Dr. Chaman Gul, Dr. Zahid Irfan Marwat, Dr. Mohammad Israr, Muhammad ArshadDepartment of Biochemistry, Ayub Medical College, Abbottabad


Nordqvist C. What Is Coronary Heart Disease (Coronary Artery Disease)? What Causes Coronary Heart Disease? [Internet]. [cited 2014 May 9]. Available from: http://www.medicalnewstoday.com/articles/184130.php

Wright M, Willacy H. Epidemiology of Coronary Heart Disease [Internet]. [cited 2014 May 9]. Available from: http://www.patient.co.uk/doctor/epidemiology-of-coronary-heart-disease

Rao VS, Kadarinarasimhiah NB, John S, Hebbaqodi S, Shanker J, Kakkar VV. Usefulness of C-reactive protein as a marker for prediction of future coronary events in the Asian Indian population: Indian atherosclerosis research study. Int J Vasc Med 2010;2010:389235.

Gorog DA. Prognostic value of plasma fibrinolysis activation markers in cardiovascular disease. J Am Coll Cardiol 2010;55(24):2701–9.

Lima LM, Sousa MO, Fernandes AP, Sabino AP, Fonseca Neto CP, Garcia JCF, et al. D-Dimer plasma levels in patients with coronary artery disease. Rev Bras Hematol E Hemoter 2006;28(4):280–3.

Ma JL, Wang S, Li XM, Su ZT, Li B, Chen GL, et al. The changes and their clinical significance of D-dimer and platelet glycoprotein in patients with coronary heart disease. Zhonghua Xin Xue Guan Bing Zaj Zhi 2005;33(8):724–6.

Lew AS, Berberian L, Cercek B, Lee S, Shah PK, Ganz W. Elevated serum D dimer: a degradation product of cross-linked fibrin (XDP) after intravenous streptokinase during acute myocardial infarction. J Am Coll Cardiol 1986;7(6):1320–4.

Tataru MC, Heinrich J, Junker R, Schulte H, Von Eckardstein A, Assmann G, et al. D-dimers in relation to the severity of arteriosclerosis in patients with stable angina pectoris after myocardial infarction. Eur Heart J 1999;20(20):1493–502.

Danesh J, Wheeler JG, Hirschfield GM, Eda S, Eiriksdottir G, Rumley A, et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med 2004;350(14):1387–97.

Danesh J, Muir J, Wong YK, Ward M, Gallimore JR, Pepys MB. Risk factors for coronary heart disease and acute-phase proteins. A population-based study. Eur Heart J 1999;20(13):954–9.

Ohsawa M, Okayama A, Nakamura M, Onoda T, Kato K, Itai K, et al. CRP levels are elevated in smokers but unrelated to the number of cigarettes and are decreased by long-term smoking cessation in male smokers. Prev Med 2005;41(2):651–6.

O’Loughlin J, Lambert M, Karp I, McGrath J, Gray-Donald K, Barnett TA, et al. Association between cigarette smoking and C-reactive protein in a representative, population-based sample of adolescents. Nicotine Tob Res 2008;10(3):525–32.

Shafi Dar M, Pandith AA, Sameer AS, Sultan M, Yousuf A, Mudassar S. hs-CRP: A potential marker for hypertension in Kashmiri population. Indian J Clin Biochem 2010;25(2):208–12.

Davey Smith G, Lawlor DA, Harbord R, Timpson N, Rumley A, Lowe GDO, et al. Association of C-reactive protein with blood pressure and hypertension: life course confounding and mendelian randomization tests of causality. Arterioscler Thromb Vasc Biol 2005;25(5):1051–6.

Mugabo Y, Li L, Renier G. The connection between C-reactive protein (CRP) and diabetic vasculopathy. Focus on preclinical findings. Curr Diabetes Rev 2010;6(1):27–34.

Lima LM, Carvalho Md, Soares AL, Sabino ade A, Femandes AP, Novelli BA, et al. High-sensitivity C-reactive protein in subjects with type 2 diabetes mellitus and/or high blood pressure. Arq Bras Endocrinol Metabol 2007;51(6):956–60.

Musicant SE, Taylor LM Jr, Peter D, Schuff RA, Uranker R, Landry GJ, et al. Prospective evaluation of the relationship between C-reactive protein, D-dimer and progression of peripheral arterial disease. J Vasc Surg 2006;43(4):772–80.

Wen D, Du X, Dong JZ, Zhou XL, Ma CS. Value of D-dimer and C reactive protein in predicting inhospital death in acute aortic dissection. Heart 2013;99(16):1192–7.



Most read articles by the same author(s)

<< < 1 2