LUNG CARCINOMA: ITS PROFILE AND CHANGING TRENDS
AbstractBackground: Lung Carcinoma is the leading causes of morbidity and mortality worldwide withan incidence of 1.3 million cases per year. This study was undertaken to determine prevalenceof various histological types of lung carcinoma and to analyse their changing trends with time.Methods: This is a retrospective analytical study. A total of 330 cases of lung carcinoma wereanalysed from 2003 to 2008. Cases from Khyber Pakhtunkhwa and Federally AdministeredTribal Area (FATA) were included in this study. Furthermore, only cases of lung carcinomawere considered while other malignancies were excluded. Results: Squamous Cell carcinomawas found in 42.7% of cases. Overall male to female ratio was 2.67:1. Prevalence of SquamousCell carcinoma increased from 32% to 57.9% while that of Small Cell carcinoma increasedfrom 12% to 17.1%. Unspecified type showed a decrease from 36% to 5.3%. Increase in theprevalence of Squamous Cell carcinoma was found in both males and females while change inthe prevalence of Small Cell carcinoma was found only in males. Conclusion: Squamous Cellcarcinoma was the most prevalent variant of lung carcinoma in our region, followed byAdenocarcinoma. Male to female ratio across different histological patterns did not showsignificant variation. Increase in the prevalence of Squamous Cell carcinoma was statisticallysignificant in both males and females while in case of Small Cell carcinoma change in itsprevalence was also significant in males.Keywords: Lung Carcinoma, Squamous Cell carcinoma, Adenocarcinoma, prevalence, profile
Wahbah M, Boroumand N, Castro C, El-Zeky F, Eltorky M.
Changing trends in the distribution of the histologic types of lung
cancer: a review of 4,439 cases. Ann Diagn Pathol
Rennert G, Rennert HS, Epstein L. Lung cancer histology in
Jews and Arabs in Israel, 1962–1982. Am Rev Respir Dis
;143(4 Pt 1):721–6.
Al-Hamdan N, Al-Jarallah M, Ravichandran K, Al-Sayyad J, AlLawati J, Khazal Z, et al. The incidence of lung cancer in the
Gulf Cooperation Council countries. Ann Saudi Med
Travis WD, Travis LB, Devesa SS. Lung cancer. Cancer
Kosacka M, Jankowska R. [The epidemiology of lung cancer].
Pneumonol Alergol Pol 2007;75(1):76–80.
Radzikowska E, Glaz P, Roszkowski K. Lung cancer in women:
age, smoking, histology, performance status, stage, initial
treatment and survival. Population-based study of 20 561 cases.
Ann Oncol 2002;13(7):1087–93.
Bhurgri Y, Bhurgri A, Usman A, Sheikh N, Faridi N, Malik J, et
al. Patho-epidemiology of lung cancer in Karachi (1995-2002).
Asian Pac J Cancer Prev 2006;7(1):60–4.
Morita T. A statistical study of lung cancer in the annual of
pathological autopsy cases in Japan, from 1958 to 1997, with
reference to time trends of lung cancer in the world. Jpn J Cancer
Perng DW, Perng RP, Kuo BI, Chiang SC. The variation of cell
type distribution in lung cancer: a study of 10,910 cases at a
medical center in Taiwan between 1970 and 1993. Jpn J Clin
Chen KY, Chang CH, Yu CJ, Kuo SH, Yang PC. Distribution
according to histologic type and outcome by gender and age
group in Taiwanese patients with lung carcinoma. Cancer
Santos-Martinez MJ, Curull V, Blanco ML, Macia F, Mojal S,
Vila J, et al. [Lung cancer at a university hospital:
epidemiological and histological characteristics of a recent and a
historical series]. Arch Bronconeumol 2005;41(6):307–12.
Choi JH, Chung HC, Yoo NC, Lee HR, Lee KH, Choi W, et al.
Changing trends in histologic types of lung cancer during the last
decade (1981-1990) in Korea: a hospital-based study. Lung
Bennett VA, Davies EA, Jack RH, Mak V, Moller H.
Histological subtype of lung cancer in relation to socio-economic
deprivation in South East England. BMC Cancer 2008;8:139.
Makitaro R, Paakko P, Huhti E, Bloigu R, Kinnula VL. An
epidemiological study of lung cancer: history and histological
types in a general population in northern Finland. Eur Respir J
Sucena M, Fernandes G, Queiroga H, Hespanhol V. [Lung
cancer--What has changed in two decades]. Rev Port Pneumol
Harkness EF, Brewster DH, Kerr KM, Fergusson RJ,
MacFarlane GJ. Changing trends in incidence of lung cancer by
histologic type in Scotland. Int J Cancer 2002;102(2):179–83.
Lee C, Kang KH, Koh Y, Chang J, Chung HS, Park SK, et al.
Characteristics of lung cancer in Korea, 1997. Lung Cancer
Migaldi M, Zunarelli E, Criscuolo M, Lauriola P, De Girolamo
G, Barbolini G. The changing histopathology of primitive lung
cancer. Pathologica 1996;88(4):297–302.
Goksel T, Akkoclu A. Pattern of lung cancer in Turkey, 1994-
Menon MA, Saw HS. Lung cancer in Malaysia. Thorax
Morita T, Sugano H. A statistical analysis of lung cancer
registered in the Annual of Pathological Autopsy Cases in Japan
between 1958 and 1987, with special reference to the
characteristics of lung cancer in Japan. Acta Pathol Jpn
Karlikaya C, Cakir Edis E. Lung cancer histopathology in the
Thrace region of Turkey and comparison with national data.
Tuberk Toraks 2005;53(2):132–8.
Kontakiotis T, Manolakoglou N, Zoglopitis F, Iakovidis D, Sacas
L, Papagiannis A, et al. Epidemiologic trends in lung cancer over
two decades in Northern Greece: an analysis of bronchoscopic
data. Monaldi Arch Chest Dis 2009;71(4):147–52.
Levi F, Franceschi S, La Vecchia C, Randimbison L, Te VC.
Lung carcinoma trends by histologic type in Vaud and
Neuchatel, Switzerland, 1974–1994. Cancer 1997;79(5):906–14.
Li X, Mutanen P, Hemminki K. Gender-specific incidence trends
in lung cancer by histological type in Sweden, 1958-1996. Eur J
Cancer Prev 2001;10(3):227–35.
Janssen-Heijnen ML, Coebergh JW. Trends in incidence and
prognosis of the histological subtypes of lung cancer in North
America, Australia, New Zealand and Europe. Lung Cancer
Liam CK, Pang YK, Leow CH, Poosparajah S, Menon A.
Changes in the distribution of lung cancer cell types and patient
demography in a developing multiracial Asian country:
experience of a university teaching hospital. Lung Cancer
Toyoda Y, Nakayama T, Ioka A, Tsukuma H. Trends in lung
cancer incidence by histological type in Osaka, Japan. Jpn J Clin
Hatcher J, Dover DC. Trends in histopathology of lung cancer in
Alberta. Can J Public Health 2003;94(4):292–6.