LUNG CARCINOMA: ITS PROFILE AND CHANGING TRENDS
AbstractBackground: Lung Carcinoma is the leading causes of morbidity and mortality worldwide withan incidence of 1.3 million cases per year. This study was undertaken to determine prevalenceof various histological types of lung carcinoma and to analyse their changing trends with time.Methods: This is a retrospective analytical study. A total of 330 cases of lung carcinoma wereanalysed from 2003 to 2008. Cases from Khyber Pakhtunkhwa and Federally AdministeredTribal Area (FATA) were included in this study. Furthermore, only cases of lung carcinomawere considered while other malignancies were excluded. Results: Squamous Cell carcinomawas found in 42.7% of cases. Overall male to female ratio was 2.67:1. Prevalence of SquamousCell carcinoma increased from 32% to 57.9% while that of Small Cell carcinoma increasedfrom 12% to 17.1%. Unspecified type showed a decrease from 36% to 5.3%. Increase in theprevalence of Squamous Cell carcinoma was found in both males and females while change inthe prevalence of Small Cell carcinoma was found only in males. Conclusion: Squamous Cellcarcinoma was the most prevalent variant of lung carcinoma in our region, followed byAdenocarcinoma. Male to female ratio across different histological patterns did not showsignificant variation. Increase in the prevalence of Squamous Cell carcinoma was statisticallysignificant in both males and females while in case of Small Cell carcinoma change in itsprevalence was also significant in males.Keywords: Lung Carcinoma, Squamous Cell carcinoma, Adenocarcinoma, prevalence, profile
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