• Azizunnisa Abbasi
  • Nazakat Begum
  • Bhagwant Devi
  • M. Hussain
  • Fareesa Waqar


During 18 months’ period (January 1994-June 1995), 64 congenitally malformed babies were delivered inObst/Gyn unit of Women and Children Hospital Abbottabad. Incidence was 2.9%. Neural tube defects were42 (65.62%), hydrocephalus 16 (25%), cleft lip and cleft palate 3 (4.68%), amelia one (1.56%), polydactylyone (1.56%) & anophthalmia one (1.56%). 13 (20.3%) mothers were primigravidas, 29 (45.31%) weremultiparas and 22 (34.37%) were grand multiparas. All of them belonged to poor socio-economic class. 9were booked and 55 (85.93%) were un booked. There was no history of X-ray exposure, drugs intake, highgrade fever or congenitally malformed babies. 4 (6.25%) mothers of babies with neural tube defects wereknown diabetics.


Gentry JT, Parkhurst E & Bulin GV:

Epidemiological study on congenital malformations in New

York state. Am J Public Health 49:497, 1959

Stevenson SS, Worcester J & Rice RG. Six

hundred and seventy-seven congenitally malformed infants

and associated gestational characteristics. Paediatrics 6: 37,

Book JA & Fraccaro M: Research on congenital

malformations. Etud Neonatal 5:39, 1956.

Gregg NM: Congenital cataract following German

measles in mothers. Trans Ophthalmol Soc Aust 3:35, 1984

Milne DB et al (1984). Effect of oral folic acid

supplements on zinc, copper and iron absorption and

excretion. Am J Clin Nutr 39: 535-539

Canton M & Cremin FM (1990). The effect of

dietary zinc depletion and repletion on rats. Br J Nutr 64:201-

MRC Vitamin Study Research Group (1991).

Prevention of Neural Tube Defects. Lancet 338, 131-137

Hurley LS (1981). Teratogenic aspect of

manganese, zinc and copper nutrition. Physiol Rev 61: 249-

Mieden GD et al (1986). Effects of whole rat

embryos culture on serum zinc and copper deficit rats. J Nutr


Smithells RW, Sheppard S & Wild J (1989).

Prevention of neural tube defects. Lancet ii, 498- 499

McIntosh R et al. Incidence of congenital

malformations. A study of 5964 pregnancies. Paediatrics

:505, 1954

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